Summary

Eligibility
for males ages 18 years and up (full criteria)
Healthy Volunteers
healthy people welcome
Location
at Los Angeles, California and other locations
Dates
study started
completion around
Principal Investigator
by Wayne Brisbane, M.D.

Description

Summary

OPTIMUM is a study designed to compare the ability of ultra-high resolution transrectal micro-ultrasound (microUS) and multiparametric MRI (mpMRI)/US fusion to guide prostate biopsy.

Official Title

Optimization of Prostate Biopsy - Micro-Ultrasound Versus MRI: A 3-arm Randomized Controlled Trial Evaluating the Role of 29MHz Micro-ultrasound in Guiding Prostate Biopsy in Men With Clinical Suspicion of Prostate Cancer.

Details

The purpose of the Clinical Investigation Plan and Study Protocol is to present information for the OPTIMUM clinical investigation, including the scientific basis for the study, the procedural details, the ExactVu High Resolution Micro-Ultrasound System, its safety details, and administrative details. It has been designed in such a way as to optimize the scientific validity and reproducibility of the results of the study in accordance with current clinical knowledge and practice so as to fulfill the objectives of the investigation.

Keywords

Prostate Cancer, prostate, prostate biopsy, micro-ultrasound, Prostatic Neoplasms, Micro-US Targeted Biopsy, MRI Targeted Biopsy, mpMRI + Micro-US

Eligibility

You can join if…

Open to males ages 18 years and up

  • Men indicated for prostate biopsy due to elevated PSA and/or abnormal DRE
  • No history of prior prostate biopsy
  • No history of genitourinary cancer, including prostate cancer
  • 18 years or older
  • No contraindications to biopsy
  • No contraindications to mpMRI
  • No history of mpMRI for clinical investigation of prostate cancer within 12 months prior to screening and enrollment in the study

You CAN'T join if...

  • History of prior prostate biopsy
  • History of genitourinary cancer, including prostate cancer
  • Contraindications to biopsy
  • Contraindications to mpMRI

Locations

  • UCLA accepting new patients
    Los Angeles California 90095 United States
  • University of Alberta accepting new patients
    Edmonton Alberta T6G1Z1 Canada

Lead Scientist at UCLA

  • Wayne Brisbane, M.D.
    Assistant Professor-in-Residence, Urology, Medicine. Authored (or co-authored) 45 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Sunnybrook Health Sciences Centre
ID
NCT05220501
Study Type
Interventional
Participants
Expecting 1200 study participants
Last Updated