Clinical Trials Open to Healthy Volunteers

A “healthy volunteer” is someone who doesn't have any major health problems, and takes part in research to test new medicines, devices, or treatments. UCLA offers clinical trials on a wide range of medical conditions. Healthy volunteers can help UCLA researchers make better comparisons to better understand the treatment of diseases.

• Age-dependent Effects of Smoked and Oral Delta-9-THC

  • study on Pain and Drug Use
  • open to healthy people ages 18-65

• Aging and Reward System Response to Inflammation and Anxiety Study

  • study on Inflammation and Anxiety
  • open to healthy people ages 60-80

• American Lung Association (ALA) Lung Health Cohort

  • study on Lung Diseases
  • open to healthy people ages 25-35

• AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)

  • study on Pain and Appetite Loss
  • open to healthy people ages 21-55

• ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

  • study on Frontotemporal Lobar Degeneration and Progressive Supranuclear Palsy
  • open to healthy people ages 18 years and up

• Behavioral Weight Loss Intervention Utilizing Mobile Health Technology in Hematopoietic Stem Cell Transplant Patients

  • study on Obesity and Bone Marrow Transplant
  • open to healthy people ages 13-30

• Biologic Therapy to Prevent Osteoarthritis After ACL Injury

  • study on ACL Injury and Immunotherapy
  • open to healthy people ages 18-35

• Brain Health in Breast Cancer Survivors

  • study on Cognitive Impairment and Cognition
  • open to healthy females ages 35-65

• BrainWeighve Weight Loss App

  • study on Weight Loss
  • open to healthy people ages 14-18

• Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.

  • study on Obesity
  • open to healthy people ages 18 years and up

• Cannabis Effects as a Function of Sex

  • study on Pain and Drug Use
  • open to healthy people ages 21-55

• Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

  • study on CADASIL and Dementia
  • open to healthy people ages 18 years and up

• Childhood Cancer Survivor Study

  • study on Cancer, General and Neoplasms
  • open to healthy people

• Clinic-wide Intervention (Primary Care-GI Connect) for Improving Rates of Colonoscopy After Abnormal Fecal Immunochemical Test Result in Patients at Federally Qualified Health Centers

  • study on Colorectal Cancer and Colorectal Tumor
  • open to healthy people

• Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

  • open to healthy people ages 1 month to 100 years

• CM for Patients With ALD After Liver Transplant

  • study on Alcohol Use and Liver Transplant
  • open to healthy people ages 18-99

• Comprehensive HHT Outcomes Registry of the United States (CHORUS)

  • study on Telangiectasia and Arteriovenous Malformation
  • open to healthy people

• Consent for Use of Stored Patient Specimens for Future Testing

  • study on HIV/AIDS
  • open to healthy people

• Continuous Glucose Monitors in Children and Adolescents With Obesity

  • study on Obesity
  • open to healthy people ages 10-21

• Cortisol and Food Insecurity

  • study on Food Insecurity and Mental Health
  • open to healthy people ages 18 years and up

• Daily Mixed Spice Consumption on Memory Function

  • study on Memory and Cognition
  • open to healthy people ages 50-80

• DBS Recordings to Characterize Movement Facilitation in Parkinson's Disease

  • study on Parkinson's Disease
  • open to healthy people ages 18 years and up

• Detecting Pulmonary Hypertension With the Eko CORE 500 Digital Stethoscope

  • study on High Blood Pressure and Pulmonary Hypertension
  • open to healthy people ages 18 years and up

• Developing a Decision Instrument to Guide Abdominal-pelvic CT Imaging of Blunt Trauma Patients

  • study on Abdominal Injury and Pelvic Fracture
  • open to healthy people

• Digital Limited Interaction Efficacy Trial of LifeSkills Mobile to Reduce HIV Incidence in YTW

  • study on HIV/AIDS and Transgender Health
  • open to healthy males ages 16-29

• DILIN - Prospective Study

  • study on Liver Disease
  • open to healthy people ages 2 years and up

• DISCOVER INOCA Prospective Multi-center Registry

  • study on Coronary Artery Disease and Peripheral Artery Disease
  • open to healthy people ages 18 years and up

• Dyadic Sleep Health Approach for Persons With Alzheimer's Disease and Caregivers

  • study on Sleep and Alzheimer's Disease
  • open to healthy people ages 18 years and up

• Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

  • study on Huntington's Disease
  • open to healthy people ages 18 years and up

• Evaluating AI-Generated Plain Language Summaries on Patient Comprehension of Ophthalmology Notes Among English-Speaking Patients

  • study on Ophthalmic Disease and Artifical Intelligence
  • open to healthy people ages 18 years and up

• Exploring, Predicting, and Intervening on Long-term Viral Suppression Electronically

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Expression of Stress Markers During Meth Treatment (EXPRESS+)

  • study on Substance Abuse and HIV/AIDS
  • open to healthy males ages 18-45

• Faith in Action! A Church-Based Navigation Model to Increase Breast Cancer Screening in Korean Women

  • study on Breast Cancer and Health Knowledge, Attitudes, Practice
  • open to healthy females ages 45-80

• Family Intervention to Prevent Childhood Obesity

  • study on Obesity
  • open to healthy people ages 2 years and up

• Fimepinostat, Combination HDAC and Pi3-kinase Inhibitor Tumor-Directed Therapy for Cushing Disease

  • study on Cushing's Syndrome
  • open to healthy people ages 18 years and up

• Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study

  • study on Cerebellar Ataxia and Friedreich's Ataxia
  • open to healthy people

• Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families

  • study on Depression and Child Development
  • open to healthy people ages 18-99

• High Potency Cannabis: Acute and Protracted Effects

  • study on Cannabis and Pain
  • open to healthy people ages 21-55

• Improving Colonoscopy Surveillance for Patients with High Risk Colon Polyps

  • study on Colorectal Cancer and Colon Polyps
  • open to healthy people ages 21 years and up

• Individuals With Autism and Germline Heterozygous PTEN Mutations

  • study on PTEN Hamartoma Tumor Syndrome and Autism
  • open to healthy people ages 18 months and up

• Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder

  • study on Post-Traumatic Stress Disorder and Insomnia
  • open to healthy people ages 50 years and up

• INSPIRE Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement

  • study on Dementia
  • open to healthy people ages 55-85

• Intervention Trial for Healthcare Workers With Anxiety

  • study on Anxiety and Emotional Regulation
  • open to healthy people ages 18 years and up

• Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

  • study on Fear and GAD
  • open to healthy people ages 18-70

• Irritable Bowel Syndrome and Control Volunteers: Diet Challenge

  • study on Irritable Bowel Syndrome
  • open to healthy people ages 17-65

• Longitudinal Early-onset Alzheimer's Disease Study Protocol

  • study on Alzheimer's Disease and Mild Cognitive Impairment
  • open to healthy people ages 40-64

• mHealth to Enhance & Sustain Drug Use Reduction of the QUIT BI in Primary Care

  • study on Drug Use
  • open to healthy people ages 18 years and up

• MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)

  • study on HIV/AIDS and Immunodeficiency
  • open to healthy people ages 16 years and up

• Neural Correlates of Real World Spatial Navigation in Humans

  • study on Memory, Delayed and Deep Brain Stimulation
  • open to healthy people ages 12-70

• Non-invasive Brain Mapping of Movement Facilitation in Parkinson's Disease

  • study on Parkinson's Disease
  • open to healthy people ages 18 years and up

• North American Prodromal Synucleinopathy Consortium Stage 2

  • study on REM Sleep Behavior Disorder and Parkinson's Disease
  • open to healthy people ages 18 years and up

• Nutrition for Precision Health, Powered by the All of Us

  • study on Nutrition and Health
  • open to healthy people ages 18 years and up

• ON-DEMAND PREP FORMULATIONS COMPARING RECTAL AND ORAL TENOFOVIR

  • study on Tenofovir and PrEP
  • open to healthy males ages 18 years and up

• Optimizing PrEP Uptake and Adherence Among Male Sex Workers

  • study on PrEP
  • open to healthy males ages 18 years and up

• Pancreatic Cancer Early Detection Consortium

  • study on Pancreatic Cancer and Pancreatic Cyst
  • open to healthy people ages 18-90

• Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

  • study on COVID-19 and High Blood Pressure
  • open to healthy people ages 0-20

• Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis

  • study on Stroke and Transient Ischemic Attack
  • open to healthy people ages 30 years and up

• Polyphenols and Cognitive Decline

  • study on Cognitive Decline and Cognitive Dysfunction
  • open to healthy people ages 50 years and up

• Practice-Based Intervention to Improve Care for a Diverse Population of Women with Urinary Incontinence

  • study on Urinary Incontinence and Overactive Bladder
  • open to healthy people ages 18 years and up

• Probiotic Intervention Study

  • study on Obesity and Food Addiction
  • open to healthy people ages 18-50

• RCT for Latina Mental Health Using Web-Based Apps

  • study on Mental Health and Anxiety
  • open to healthy females ages 18 years and up

• Regional Blocks for Lateral Condyle Fractures

  • study on Fractures, Closed and Humerus Fracture
  • open to healthy people ages 4-12

• Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women

  • study on Pregnancy and Depression
  • open to healthy females ages 18-65

• Retro-active Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-identical Kidney Transplants

  • study on End Stage Renal Disease and Kidney Disease
  • open to healthy people ages 18 years and up

• See if an iPhone Weight Management App Can Help Promote Weight Loss in Adolescents and Young Adults After a Stem Cell Transplant

  • study on Obesity and Malignant Neoplasm
  • open to healthy people ages 13-30

• Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma

  • study on Glioma and Brain Tumor
  • open to healthy people ages 18 years and up

• Smoked THC and CBD in Men and Women

  • study on Drug Use and Intoxication by Drug
  • open to healthy people ages 21-55

• Snacks on Aging

  • open to healthy females ages 55-75

• Social Facilitation of Emotion Regulation in Adolescence

  • study on Emotional Regulation
  • open to healthy people ages 13-25

• Social Support and Enhanced Fear Extinction

  • study on Fear and Anxiety
  • open to healthy people ages 18-55

• Social Support and Reduced Fear Acquisition

  • study on Fear and Anxiety
  • open to healthy people ages 18-55

• SPIROMICS Study of Early COPD Progression (SOURCE)

  • study on Chronic Obstructive Pulmonary Disease
  • open to healthy people ages 30-55

• Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

  • study on Diabetes and Diabetes Type 2
  • open to healthy people ages 55 years and up

• Standard Endoscopic Hemostasis Versus OVESCO Severe Non-variceal UGI Hemorrhage

  • study on Upper Gastrointestinal Hemorrhage
  • open to healthy people ages 18-100

• Students Rising Above: Offsetting the Health and Mental Health Costs of Resilience

  • study on Internalizing Mental Health Symptoms and Allostatic Load
  • open to healthy people ages 13 years and up

• T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses

  • study on COVID-19 and Vaccine
  • open to healthy people ages 40-64

• Testing the Effect of the Youth Mindful Awareness Program on Negative Affect (YMAP2).

  • open to healthy people ages 12-17

• THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments

  • study on Adverse Childhood Experiences and Family Functioning
  • open to healthy people ages 11-14

• TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)

  • study on Barrett's Esophagus and Esophageal Cancer
  • open to healthy people ages 18-100

• TrialNet Pathway to Prevention of T1D

  • study on Diabetes and Diabetes Type 1
  • open to healthy people ages 2-45

• UCLA Perinatal Biospecimen Repository

  • study on Pregnancy
  • open to healthy people

• UCLA REST Study (REsearch on Sleep Techniques)

  • study on Sleep Disorders and Inflammation
  • open to healthy people ages 18-20

• Utilizing Advocates and Supporters to Increase Lung Cancer Screening Rates in Eligible Participants

  • study on Breast Cancer and Lung Cancer
  • open to healthy people ages 40-80

• VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)

  • study on Von Willebrand Disease and Blood Coagulation Disorder
  • open to healthy people ages 12-60

• Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

  • study on Breast Cancer and Cancer, General
  • open to healthy females ages 30-74

• Work Time Schedule Changes for Nurse Managers

  • study on Work-Related Condition
  • open to healthy people ages 18 years and up

• Writing About Experiences and Health in Older Adults II

  • study on Social Psychology
  • open to healthy people ages 65 years and up

Current as of: September 16, 2025