A Study to Investigate Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis

Open to people ages 50 years and up

1. Adult male or female at least 50 years of age
2. Has moderate CAVS as defined by:
   1. An AVA of ≥1 cm2 to ≤1.50 cm2
   2. An AVC score between ≥600 to 1200 Agatston units (AU) for women and between ≥600 to 2000 AU for men
3. Has a left ventricular ejection fraction (EF) of ≥45% at the time of Screening as determined by the echocardiography Core Laboratory
4. Can perform Cardiopulmonary Exercise Testing (CPET)

1. Has had a prior aortic valve replacement, repair, surgery, or intervention
2. Has moderate, moderate-to-severe, or severe (Grade 2 or higher) mitral stenosis, mitral regurgitation, and/or aortic regurgitation
3. Has known congenital aortic valve disease including bicuspid aortic valve
4. New York Heart Association (NYHA) Class III or Class IV
5. Has heart failure such as cardiomyopathy, congenital heart disease, myocarditis
6. Has coronary artery disease or anticipating coronary stenting surgery
7. Abnormal electrocardiogram (ECG) results or long-standing persistent or permanent atrial fibrillation