Summary

Eligibility
for people ages 13-24 (full criteria)
Location
at Los Angeles, California
Dates
study started
completion around
Principal Investigator
by Elaine L. Rosen, MD

Description

Summary

Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.

Official Title

Secretin Levels in Refeeding-induced Polyuria (Cross Section)

Keywords

Anorexia in Adolescence, Anorexia, dumpers

Eligibility

You can join if…

Open to people ages 13-24

  • Group 1:
    • male and female patients
    • age 13-24 years
    • diagnosis of restrictive-type anorexia nervosa
    • hospitalization for nutritional support
    • >4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)
  • Group 2:
    • male and female patients
    • age 13-24 years
    • diagnosis of restrictive-type anorexia nervosa
    • hospitalization for nutritional support
    • <2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)

You CAN'T join if...

  • 5150 hold
  • Anti-depressant, anti-psychotic, or anticonvulsant medications
  • Previous hospitalization within the past 6 months
  • Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders)
  • Pregnancy
  • NG or G-tube feeds after day 2 of hospitalization
  • > 10% of nutritional needs from supplemental feeds

Location

  • University of California, Los Angeles (UCLA) accepting new patients
    Los Angeles California 90095 United States

Lead Scientist at UCLA

  • Elaine L. Rosen, MD
    HS Associate Clinical Professor, Pediatrics, Medicine. Authored (or co-authored) 12 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT05235867
Study Type
Observational
Participants
Expecting 10 study participants
Last Updated