Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at Los Angeles, California and other locations
Dates
study started
completion around

Description

Summary

This is a first-in-human (FIH), Phase 1a/1b open-label, multicenter, dose escalation and dose expansion study of SW-682 in adult participants with metastatic or unresectable advanced solid tumors with or without Hippo pathway alterations that are refractory to, or have progressed, during or after appropriate prior systemic anticancer therapy, including chemotherapy, immunotherapy, radiation therapy or targeted therapy, or for which no treatment is available, or prior standard of care (SOC) therapy was not tolerated and for which there is no further SOC treatment available. The study includes a Part 1 (Phase 1a) dose escalation phase and a Part 2 (Phase 1b) dose expansion to optimize the dose to be used for further development. All participants will self-administer SW-682 by mouth in 28-day cycles.

Official Title

A Phase 1a/1b Dose Escalation, Dose Expansion Study of SW-682 in Participants With Advanced Solid Tumors Enriched for Those With Hippo Pathway Mutations

Keywords

Advanced Solid Tumor, Mesothelioma, Malignant, Mesothelioma, Malignant Mesothelioma, Combination Therapy

Eligibility

You can join if…

Open to people ages 18 years and up

  • Histologically confirmed, metastatic, or unresectable solid cancer that has either not responded to or progressed during or after appropriate prior systemic anticancer therapy including chemotherapy, immunotherapy, radiation therapy, or appropriate targeted therapy, or for which there is no treatment available or prior SOC therapy was not tolerated and for which there is no further SOC treatment available
  • Part 1: must have one of the following:
    • Mesothelioma with or without NF2 mutations
    • Advanced solid tumors with NF2 mutations
    • Advanced solid tumors with other Hippo pathway mutations or fusions (e.g., FAT1, LATS1/2, YAP fusions; WWTR1-CAMTA1 in EHE).
  • Part 2: must have the tumor histology and oncogenic mutation or genomic aberration specific to each dose expansion cohort defined below:
    • Cohort 1: Participants with mesothelioma with or without NF2 mutations
    • Cohort 2: Participants with advanced solid tumors with NF2 mutations
    • Cohort 3: Participants with advanced solid tumors with other Hippo pathway mutations identified during Part 1 (Phase 1a) dose escalation
    • Cohort 4: SW-682 with appropriate combination therapy.
  • In both parts, participants should have known oncogenic mutation identified by Next Generation Sequencing or local assay
  • Must have archival tumor tissue or agree to a fresh tumor biopsy at screening
  • Measurable disease per RECIST 1.1
  • Eastern Cooperative Oncology Group (ECOG) performance status of ≤1
  • Adequate bone marrow, kidney, hepatic, and coagulation function

You CAN'T join if...

  • Evidence of symptomatic CNS metastases, leptomeningeal carcinomatosis, or untreated spinal cord compression
  • Clinically significant cardiac disease or abnormal cardiac parameters
  • Preexistence or inheritance of a familial renal syndrome
  • Concomitant non-anti-arrhythmic medications that are known to prolong the QTc interval
  • Concomitant medicines that are known strong/moderate inhibitors or inducers of cytochrome P450 3A4 (CYP3A4) and/or CYP1A2 within 14 days or 5 half-lives before the first dose of study treatment
  • Concomitant medicines that are known sensitive substrates of CYP3A4, CYP2C19, CYP2D6, CYP1A2, and/or CYP2B6 within 14 days or 5 half-lives before the first dose of study treatment
  • Concomitant medicines that are known sensitive substrates of PGP, BCRP, OATP1B1, OATP1B3, OAT1, OAT3, MATE1, MATE2-K, OCT2
  • Clinically significant active infection (bacterial, fungal, or viral)

Locations

  • SpringWorks Clinical Trial Site in progress, not accepting new patients
    Los Angeles California 90095 United States
  • USC/Norris Comprehensive Cancer Center accepting new patients
    Los Angeles California 90033 United States
  • SpringWorks Clinical Trial Site accepting new patients
    Scottsdale Arizona 85258 United States

Details

Status
accepting new patients at some sites,
but this study is not currently recruiting here
Start Date
Completion Date
(estimated)
Sponsor
SpringWorks Therapeutics, Inc.
ID
NCT06251310
Phase
Phase 1 research study
Study Type
Interventional
Participants
Expecting 186 study participants
Last Updated