A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

a study on Head and Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Head and Neck Cancer Neoplasms

Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at Los Angeles, California and other locations
Dates
study started
study ends around
Principal Investigator
by Deborah Wong

Description

Summary

The study is a prospective, longitudinal, non-interventional, multicenter study of participants with HNSCC who will have tissue and blood based molecular biomarker profiling during their standard of care treatment.

Official Title

TEMPUS PHOENIX HNSCC STUDY: A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

Keywords

Head and Neck Squamous Cell Carcinoma, Oncology, Biomarkers, Genomic Profiling, HNSCC, Cancer, Observational, Registry, Precision Medicine, NGS, Squamous Cell Carcinoma of Head and Neck, Neoplasms

Eligibility

You can join if…

Open to people ages 18 years and up

  • ≥18 years of age
  • Willing and able to provide informed consent
  • Histologically- or cytologically-confirmed metastatic or unresectable, recurrent HNSCC unsuitable for local therapies
  • Intended for first line anti-PD1 or PDL1 monotherapy or combination therapy
  • Must submit tumor tissue sample representative of current disease per laboratory manual

You CAN'T join if...

  • Non-squamous histologies (eg, nasopharynx or salivary gland)
  • Relapse or recurrence within 6 months of first line chemotherapy and / or chemoradiotherapy
  • Tumors that are PD-L1 negative (CPS <1)
  • Clinical evidence of an active second invasive malignancy within <2 years of enrollment with the exception of stable prostate cancer on watchful waiting, in situ cervical cancer, in situ breast carcinoma or localized non-melanoma skin cancers
  • Unable to comply with study procedures (i.e., not willing or able to have additional blood samples collected)

Locations

  • University of California, Los Angeles accepting new patients
    Los Angeles California 90095 United States
  • USC/Norris Comprehensive Cancer Center accepting new patients
    Los Angeles California 90033 United States
  • City of Hope accepting new patients
    Duarte California 91010 United States

Lead Scientist at UCLA

  • Deborah Wong
    HS Associate Clinical Professor, Medicine. Authored (or co-authored) 53 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Tempus AI
Links
Sign up for this study
ID
NCT06163534
Study Type
Observational [Patient Registry]
Participants
Expecting 500 study participants
Last Updated
Contact us about this trial