A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors

a study on Cancer, General Lung Cancer Solid Tumor Lung Tumor

Eligibility: for people ages 18 years and up (full criteria)
Location: at Santa Monica, California and other locations
Dates: study started June 2023
completion around December 2025
Principal Investigator: by Lee S. Rosen, MD

Description

Summary

The goal of this clinical trial is to test CPO301, a type of drug called an antibody drug conjugate in adult patients with advanced or metastatic solid tumors.

The main questions it aims to answer are:

To assess the safety and tolerability of CPO301 at increasing doses and determine the dose to be used in the second part of the study (Part A)
To assess the safety and tolerability of CPO301 at the dose determined to be safe and tolerable in Part A in patients with Non-Small Cell Lung Cancer and potentially other tumor types (Part B)
To evaluate how quickly CPO301 is metabolized by the body (pharmacokinetics or PK)
To evaluate if antibodies to the study drug develop (immunogenicity)
To evaluate preliminary efficacy to the drug
To correlate preliminary efficacy with mutations in a biomarker called EGFR

Participants will:

Provide written informed consent
Undergo screening tests to ensure they are eligible for study treatment
Attend all required study visits and receive CPO301 by intravenous injection every 3 weeks until the study doctor determines study treatment should be stopped, based on how well a participant is doing on treatment
Be followed for progression every 3 months for up to 2 years

Official Title

A Phase 1, Multicenter, Single Agent Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of CPO301, an EGFR-Targeting Antibody-Drug Conjugate, in Adult Patients With Advanced or Metastatic Solid Tumors

Details

This Phase 1 study is a multicenter, dose-escalating, dose-expansion, single agent, 2-part study conducted in patients with advanced or metastatic solid tumors who progressed on ≥1 prior conventional systemic therapy or who were ineligible or intolerant to standard treatment or had no or refused standard treatment.

Dose escalation (Part A) - Dose escalation will be guided by a modified 3+3 design to determine the maximum tolerated dose (MTD) or recommended dose of CPO301 (also known as SYS6010). Determination of dose-limiting toxicity (DLT) will be based on toxicity observed during the DLT observation period (first 21 days [1 cycle]). Dose escalation decisions are made based on the occurrence of DLT. MTD will be determined based on the data of all enrolled participants. To better identify the MTD, one or more dose groups may also be added beyond the planned maximum dose group (if determined to be safe), or between the maximum escalation dose group and the next lower dose group for DLT assessment. Intermediate dose groups and/or adjustment to the dosing frequency may be made

Dose expansion (Part B) - Additional patients will be enrolled at the recommended dose determined in the dose escalation stage. An additional tumor cohort may be added based on data observed in Part A.

Keywords

Cancer, Cancer, Lung, Non-Small Cell Lung Cancer, Solid Tumors, Metastatic, Advanced, Lung Neoplasms, CPO301

Eligibility

For people ages 18 years and up

Major Inclusion Criteria:

Age ≥18 years
Patients with histologically confirmed locally advanced or metastatic solid tumors who have disease progression, intolerance to prior therapy, are ineligible for available therapies, or refuse standard of care therapy in the metastatic setting.
In Part A, patients with solid tumors including but not limited to NSCLC (adenocarcinoma and squamous cell carcinoma), breast cancer, KRAS-wild type colorectal cancer, and head & neck cancer based on previous biopsy result.
In Part B, Cohort 1 will exclusively include NSCLC patients with documented EGFR mutations based on previous biopsy result and Cohort 2 will be patients with other cancer(s) suggested to have sensitivity to CPO301 in Part A.
At least 1 measurable target lesion present and documented by CT or MRI according to RECIST v1.1
ECOG performance status 0 or 1 at screening
Life expectancy >12 weeks

Major Exclusion Criteria:

Known, active, or uncontrolled central nervous system (CNS) metastasis or carcinomatous meningitis.
Has AEs due to previous anti-tumor treatments not recovered to ≤Grade 1 (except for alopecia; some tolerable chronic toxicities of Grade 2 may be excluded after consultation with the sponsor, as judged by the investigator) according to NCI-CTCAE v5.0.
Any serious and/or uncontrolled concurrent illness that may interfere with study participation

Prior therapy

Received other investigational drugs or treatments within 4 weeks before the first dose of the investigational drug in the study
The time interval between the latest anti-tumor treatment and the first dose of the investigational drug meets the following requirements: Have received anti-tumor treatments such as chemotherapy, radiotherapy, targeted therapy, immunotherapy and other clinical investigational drugs within 4 weeks before the first dose of the investigational drug; have received oral fluoropyrimidines, small molecule targeted drugs within 2 weeks before the first dose of the investigational drug; have received palliative radiotherapy or local therapy within 2 weeks before the first dose of investigational drug.
Had major surgery within 4 weeks before the first dose of the investigational drug in the study.

Locations

UCLA Hematology/Oncology - Santa Monica accepting new patients
Santa Monica California 90404 United States
USC Norris Comprehensive Cancer Center accepting new patients
Los Angeles California 90033 United States

Lead Scientist at UCLA

Lee S. Rosen, MD
HS Clinical Professor, Medicine. Authored (or co-authored) 115 research publications

Details

Status: accepting new patients
Start Date: June 2023
Completion Date: December 2025 (estimated)
Sponsor: Conjupro Biotherapeutics, Inc.
ID: NCT05948865
Phase: Phase 1 research study
Study Type: Interventional
Participants: Expecting 102 study participants
Last Updated: June 2024