Summary
This study aims to determine the safety, preliminary antitumor activity, and pharmacokinetics (PK) of RYZ101 in combination with standard of care (SoC) therapy consisting of carboplatin + etoposide + atezolizumab in untreated subjects with somatostatin receptor expressing (SSTR+) ES-SCLC.
Official Title
Phase 1b Single Arm, Open-label Trial of RYZ101 in Combination With Carboplatin + Etoposide + Atezolizumab in Subjects With Somatostatin Receptor Expressing (SSTR+) Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Keywords
SCLC,Extensive Stage, actinium, alpha-emitter, SSTR+ ES-SCLC, SCLC, ES-SCLC, RYZ101, 225Ac, 225Ac-DOTATATE, targeted radiotherapy, atezolizumab, carboplatin, etoposide, radiopharmaceutical, Small Cell Lung Carcinoma, RYZ101 Dose Level 1, RYZ101 Dose Level 2, RYZ101 Dose Level 3, RYZ101 Dose Level -1