Summary

Eligibility
for people ages 18-65 (full criteria)
Location
at Los Angeles, California
Dates
study started
completion around
Principal Investigator
by Stephen Marder, MD

Description

Summary

This study will measure whether the engagement of intranasal oxytocin with a brain target is related to effects on learning during a social cognition training program.

Official Title

Effects of Oxytocin on Social Cognition Training: Relationship to Target Engagement

Details

The study will determine whether oxytocin (OT) administration 30 min before a training session enhances the learning of social information in the context of a social cognitive skills training (SCST) program, and it will test a possible mediator of this effect. Subjects with psychotic disorders will be randomized to one of four groups in a 2 by 2 factorial design: OT with SCST; Placebo with SCST; OT with training control condition; placebo with training control condition. Target engagement will be measured in an OT challenge (placebo versus OT one week apart) prior to baseline assessment. The measure of target engagement will be EEG mu suppression while observing biological motion. A social cognition battery will be administered at baseline, at midpoint after 6 weeks of SCST, and at completion of training at 12 weeks. The battery will include measures of social cue identification and mentalizing.

Keywords

Schizophrenia, Social Cognition, Oxytocin, Oxytocin nasal spray, Social Cognition Skills Training, Health Management

Eligibility

You can join if…

Open to people ages 18-65

You CAN'T join if...

Location

  • UCLA
    Los Angeles California 90073 United States

Lead Scientist at UCLA

  • Stephen Marder, MD
    Dr. Stephen Marder holds the Dr. Daniel X. Freedman Administrative Chair in Academic Psychiatry.

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT03245437
Phase
Phase 4 Schizophrenia Research Study
Study Type
Interventional
Participants
Expecting 120 study participants
Last Updated