Syphilis clinical trials at UCLA
3 in progress, 1 open to eligible people
Modernizing Perinatal Syphilis Testing
open to eligible people ages up to 45 years
The purpose of this study is to determine the testing performance of real-time quantitative polymerase chain reaction and transcription mediated amplification by comparing test performance of these novel molecular tests to current 2021 CDC CS guidelines for maternal/neonatal dyads at risk for syphilis infection and to determine whether CS is associated with adverse neurodevelopmental outcomes.
Los Angeles 5368361, California 5332921 and other locations
Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
Sorry, currently not accepting new patients, but might later
The goal of this open-label, randomized trial is to assess the efficacy of doxycycline prophylaxis in reducing incidences of bacterial sexually transmitted infections (STIs) among adolescent and young adult females while also evaluating acceptability and antimicrobial resistance in order to inform public health policy.
Los Angeles 5368361, California 5332921 and other locations
Ceftriaxone and Benzathine Penicillin G During Pregnancy
Sorry, not yet accepting patients
IMPAACT 2044 is a study to characterize the pharmacokinetics (PK) and safety of ceftriaxone and benzathine penicillin G during pregnancy. Up to 78 pregnant women receiving (1) ceftriaxone for indications other than syphilis or (2) benzathine penicillin G for treatment of syphilis from non-study clinical care providers will be enrolled at study sites located in the United States. Approximately 22 infants of pregnant participants receiving benzathine penicillin G will also be enrolled.
Los Angeles 5368361, California 5332921 and other locations
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