PrEP clinical trials at UCLA
6 in progress, 5 open to eligible people
EASE: The Materna Prep Pivotal Study
open to eligible females ages 18 years and up
This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery. Subjects are randomized to Materna Prep Device or Standard of Care without use of the Materna Prep Device Intervention with the Materna Prep Device is expected to be a one-time use of approximately 30-90 minutes during the 1st stage of labor. Subject participation in the study is targeted to be 12 months from the time of the use of the device during delivery.
Los Angeles, California and other locations
Latino MSM Focused Pre-Exposure Prophylaxis Uptake Intervention
open to eligible males ages 18 years and up
The clinical study will evaluate the feasibility and acceptability of a culturally tailored behavioral intervention to improve uptake of pre-exposure prophylaxis for HIV prevention among at-risk Latino men who have sex with men.
Los Angeles, California
Adaptive Intervention to Facilitate PrEP Uptake/Adherence Among Transgender Women
open to eligible males ages 18 years and up
"PrEP N' Shine" is a two-stage randomized controlled pilot trial which utilizes a behavioral intervention to optimize the uptake and adherence of Pre-exposure Prophylaxis (PrEP) in Transgender women (TGW).
Los Angeles, California
ASK-PrEP (Assistance Services Knowledge-PrEP)
open to eligible males ages 18 years and up
ASK-PrEP is a two-arm randomized controlled trial (RCT), with a Stepped Care approach, among HIV-negative trans women and men who have sex with men with a substance use disorder (SUD). Participants will be randomized (3:1) to the ASK-PrEP Stepped Care arm or Standard of Care (SOC). Participants in the ASK-PrEP Stepped Care arm will receive 5 PrEP navigation sessions, with weekly text-messaging support, delivered over 3 months, at which point they will be assessed for intervention response. Responders will be maintained for an additional 3 months in ASK-PrEP to receive an additional 5 PrEP navigation session with weekly text-messaging support, while non-responders will receive added attention to their SUD via contingency management (CM). Non-responders will be re-randomized (1:1) to either a) receive ASK-PrEP + CM, or b) shift the primary focus to their SUD (CM alone) for an additional 3 months.
Los Angeles, California
Optimizing PrEP Uptake and Adherence Among Male Sex Workers
open to eligible males ages 18 years and up
"PrEPare for Work" is a randomized controlled trial (RCT) whose goal is to test the efficacy of a behavioral intervention (Short Title: PrEPare for Work) in improving PrEP uptake, adherence, and persistence among male sex workers (MSW)
Los Angeles, California and other locations
Lenacapavir for HIV Pre-Exposure Prophylaxis in People Who Are at Risk for HIV Infection
Sorry, in progress, not accepting new patients
The goal of this clinical study is to test how well the study drug, lenacapavir (LEN), works in preventing the risk of HIV.
Los Angeles, California and other locations
Our lead scientists for PrEP research studies include Tamara Grisales Ronald A Brooks, PhD Matthew Mimiaga, ScD, MPH, MA.
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