Multiple Sclerosis clinical trials at UCLA
4 in progress, 2 open to eligible people
Continued Current Therapy vs Transition to Ofatumumab After Neurofilament (NfL) Elevation
open to eligible people ages 18-50
This study will evaluate if relapsing-remitting MS patients that have not had a relapse in the past year would benefit from a switch to ofatumumab versus staying on their continued current therapy. This study will also look at whether an elevated serum neurofilament light (NfL) level predicts enhanced benefit from a switch to ofatumumab.
Torrance, California and other locations
Metformin Treatment in Progressive Multiple Sclerosis
open to eligible people ages 30-65
The purpose of this study is to assess the safety of metformin for treatment of progressive multiple sclerosis
Los Angeles, California
Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS)
Sorry, in progress, not accepting new patients
Primary Objective: To determine the efficacy of SAR442168 compared to placebo in delaying disability progression in primary progressive multiple sclerosis (PPMS) Secondary Objectives: To evaluate efficacy of SAR442168 compared to placebo on clinical endpoints, magnetic resonance imaging (MRI) lesions, cognitive performance, physical function, and quality of life To evaluate safety and tolerability of SAR442168 To evaluate population pharmacokinetics (PK) of SAR442168 in PPMS and its relationship to efficacy and safety To evaluate pharmacodynamics of SAR442168
Torrance, California and other locations
Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
Sorry, in progress, not accepting new patients
A study to evaluate the efficacy and safety of fenebrutinib on disability progression and relapse rate in adult participants with RMS. Eligible participants will be randomized 1:1 to either fenebrutinib or teriflunomide. Open-Label Extension (OLE) phase is contingent on a positive benefit-risk result in the Primary Analysis of the study.
Torrance, California and other locations
Our lead scientists for Multiple Sclerosis research studies include Kevin R Patel, MD.
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