Emphysema clinical trials at UCLA
4 in progress, 1 open to eligible people
Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
open to eligible people ages 30 years and up
The purpose of this study is to determine if doxycycline will reduce progression of emphysema in people living with HIV. The secondary objectives are to examine the effects of doxycycline on change in quantity of emphysema, six minute walk distance, patient reported outcomes, ratio of forced expiratory volume in 1 second and forced vital capacity. Secondary objectives will also describe the safety and tolerability of doxycycline and determine if doxycycline is associated with development of antibiotic-resistant bacterial infections.
Los Angeles, California and other locations
Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency
Sorry, in progress, not accepting new patients
This is a Phase 2, multicenter, double-blind, randomized (1:1), placebo-controlled, 12-week, proof-of-concept study to evaluate the safety and tolerability as well as the mechanistic effect of oral administration of alvelestat (MPH966) in subjects with confirmed AATD defined as Pi*ZZ, Pi*SZ, Pi*null, or another rare phenotype/genotype known to be associated with either low (serum AAT level <11 μM or <57.2 mg/dL) or functionally impaired AAT including "F" or "I" mutations.
Los Angeles, California and other locations
INBRX-101 Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema
Sorry, not currently recruiting here
Phase 2 study to compare INBRX-101 to plasma derived A1PI therapy in adults with AATD emphysema
Los Angeles, California and other locations
COPD Subgroups and Biomarkers
Sorry, in progress, not accepting new patients
SPIROMICS I and SPIROMICS II are observational studies of Chronic Obstructive Pulmonary Disease (COPD). SPIROMICS I had two main aims: (1) To find groups of patients with COPD who share certain characteristics; (2) To find new ways of measuring whether or not COPD is getting worse and so provide new ways of testing whether a new treatment is working. SPIROMICS II has three primary aims. Aim 1 is to define the natural history of "Smokers with symptoms despite preserved spirometry" and characterize the airway mucus abnormalities underlying this condition. Aim 2 is to determine the radiographic precursor lesion(s) for emphysema, and identify the molecular phenotypes underlying airway disease and emphysema. Aim 3 is to advance understanding of the biology of COPD exacerbations through analysis of predisposing baseline phenotypes, exacerbation triggers and host inflammatory response.
Los Angeles, California and other locations
Our lead scientists for Emphysema research studies include Igor Barjaktarevic, MD John Belperio.
Last updated: