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Drug Use clinical trials at UCLA

8 in progress, 6 open to eligible people

Showing trials for
  • AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)

    open to eligible people ages 21-55

    This study will assess the analgesic, appetite-stimulating, and subjective effects of cannabigerol (CBG) alone and in combination with THC.

    Los Angeles, California

  • Analgesic and Subjective Effects of Terpenes

    open to eligible people ages 21-55

    The purpose of this research is to assess the analgesic and subjective effects of terpenes administered alone and in combination of THC.

    Los Angeles, California

  • Cannabis Effects as a Function of Sex (CanSex)

    open to eligible people ages 21-55

    The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women

    Los Angeles, California

  • Smoked THC and CBD in Men and Women

    open to eligible people ages 21-55

    The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.

    Los Angeles, California

  • Age-dependent Effects of Smoked and Oral Delta-9-THC

    open to eligible people ages 18-65

    This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.

    Los Angeles, California

  • MHealth to Enhance & Sustain Drug Use Reduction of the QUIT BI in Primary Care

    open to eligible people ages 18 years and up

    The QUIT-Mobile study proposes to use mobile phone self-monitoring and feedback to enhance and sustain over 12-months the impacts of the Quit Using Drugs Intervention Trial (QUIT), an effective screening and brief intervention (SBI) previously successful in reducing risky drug use (i.e., moderate use) in low-income, diverse patients over a 3-month follow up. The investigators will conduct the QUIT-Mobile study for patients who receive care in clinics of federally qualified health centers (FQHC) in Southern California over 12-months follow up. The study is an Effectiveness-Implementation Hybrid Type 1 design consisting of a single-blind, 3-arm, RCT with adult, mostly Latino FQHC primary care patients with risky drug use (ASSIST score 4-26), randomized to 3 conditions (n=200/arm, n=600 total): 1) QUIT-Mobile; 2) standard QUIT; 3) Usual Care. Qualitative data on implementation facilitators and barriers will inform future scale-up and sustainability, in addition to cost data analyses. The aims are to examine effectiveness in reducing risky drug use and cost-effectiveness comparing the three arms over 3-, 6- and 12-months. Drug use measures include self-reports for past 30-days and urine drug screen validation for underreporting (acknowledging that people with moderate risk drug use have sporadic drug use patterns requiring longer self-report recalls for drug use that urine screens may not detect). The 3-arm study enables testing of the independent and synergistic effects of QUIT-Mobile compared to QUIT and both to Usual Care. The 12-month timeline reflects annual primary care visits when screening and brief intervention would be repeated routinely. The QUIT intervention contains 3 primary components: 1) patient screening with the WHO ASSIST, 2) brief clinician advice (<3 minutes) including opioid overdose prevention education, and 3) 2- and 6-week telephone drug-use health coaching sessions utilizing motivational interviewing and cognitive behavioral techniques, delivered by paraprofessional health coaches. QUIT-Mobile tests the addition of mobile phone self-monitoring, automated feedback, and coach monitoring dashboard to enhance and sustain QUIT's drug use reductions using mobile-web app, text-messaging (SMS), or interactive voice response (IVR).

    Los Angeles, California and other locations

  • Oral THC and CBD in Men and Women

    Sorry, not yet accepting patients

    The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of oral delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.

    Los Angeles, California

  • THC and CBD: a Controlled Human Study Probing a Harm Reduction Strategy

    Sorry, not yet accepting patients

    The purpose of this research is to assess the impact of CBD on the effects of THC.

Our lead scientists for Drug Use research studies include .

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